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IS THERE A CORRELATION BETWEEN PLACENTAL LEPTIN AND MATERNAL GESTATIONAL FACTORS WITH ANTHROPOMETRIC DATA OF THE NEWBORN? / HÁ CORRELAÇÃO ENTRE LEPTINA PLACENTÁRIA E FATORES MATERNOS GESTACIONAIS COM DADOS ANTROPOMÉTRICOS DO RECÉM-NASCIDO?
SciELO Preprints; jun. 2022.
Preprint
in Pt
| PREPRINT-SCIELO
| ID: pps-4259
Responsible library:
BR1.1
ABSTRACT
Introduction:
Leptin in maternal/fetal compartments, and its mechanisms, are being elucidated. Hormonal factors, genetic predisposition, chromosomal formation, environmental conditions, infections and the use of toxic substances may be related to negative outcomes in pregnancy, the fetus and the neonate.Objective:
To analyze the correlation of placental leptin with maternal gestational factors and anthropometric data on the newborn.Method:
Cross-sectional, descriptive, uncontrolled study. The sample consisted of 103 parturients and their respective newborns (NB). They were arranged according to the presented gestational risk factors and usual risk factors, and later, blood was collected from the placental fragments, for the serum leptin dosage. Gestational age, weight, height, BMI and head circumference were evaluated.Results:
There was no statistically significant difference in leptin distribution below or above 0.1 in mothers with and without gestational risk factors. However, there was a trend in those with diabetes and obesity. Regarding the assessment of the presence and absence of maternal gestational factors between them and the level of placental leptin, only the obesity factor was significant. When the association between NB characteristics and leptin values was evaluated, no significant difference was observed; however, when related to gender, there was twice as much in females. In the assessment between weight/GA with placental leptin, there was no difference, but it was superior in big for gestational age NBs.Conclusion:
Placental leptin was correlated with maternal gestational obesity risk, but without correlation with NB anthropometric data.RESUMO
Introdução:
lLeptina nos compartimentos materno/fetais, e seus mecanismos, estão sendo elucidados. Fatores hormonais, predisposição genética, formação cromossômica, condições ambientais, infecções e a utilização de substâncias tóxicas podem estar relacionadas a desfechos negativos na gestação, no feto e no neonato.Objetivo:
Analisar a correlação da leptina placentária com fatores maternos gestacionais e dados antropométricos do recém-nascido.Método:
Estudo transversal, descritivo, não controlado. A amostra constou de 103 parturientes e seus respectivos recém-nascidos (RN). As parturientes foram dispostas conforme os fatores de risco gestacionais apresentados e fatores de risco habituais, e posteriormente coletado sangue dos fragmentos placentários, para a dosagem sérica da leptina. Foram avaliados a idade gestacional, peso, estatura, IMC e perímetro cefálico.Resultados:
Não houve diferença estatisticamente significativa na distribuição da leptina inferior ou superior a 0,1 em mães com e sem os fatores de risco gestacionais. No entanto verificou-se tendência naquelas com diabete e obesidade. Quanto à avaliação da presença e ausência de fatores maternos gestacionais entre si e o nível de leptina placentária, apenas o fator obesidade foi significante. Quando avaliada a associação entre as características do RN e os valores de leptina não foi observada diferença significativa; no entanto, houve quando relacionada ao gênero, o dobro no sexo feminino. Na avaliação entre peso/IG com leptina placentária não houve diferença, porém foi superior em RN's grande para a idade gestacional.Conclusão:
A leptina placentária apresentou correlação com o risco materno gestacional de obesidade, mas sem correlação com a antropometria do RN.
Full text:
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Collection:
09-preprints
Database:
PREPRINT-SCIELO
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Language:
Pt
Year:
2022
Document type:
Preprint