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CAN LOCAL ANESTHETICS HELP WITH THE HEALING PROCESS OF SURGICAL WOUNDS? / PODEM OS ANESTÉSICOS LOCAIS AJUDAR NO PROCESSO CICATRICIAL DAS FERIDAS CIRÚRGICAS?
Preprint
in Portuguese
| SciELO Preprints
| ID: pps-7987
Responsible library:
BR1.1
ABSTRACT
Introduction:
Evaluating the scarring differences between areas previously anesthetized with different local anesthetics is interesting to verify whether the choice of anesthetic helps in surgical healing in relation to inflammation, neovascularization and collagen deposition.Objectives:
Review the existing literature with a focus on analyzing the role of local anesthetics in aiding the healing of surgical wounds.Method:
Narrative review of literature selected from the SciELO Scientific Electronic Library Online, Google Scholar, Pubmed and Scopus platforms. Initially, the review searched for keywords in the focus of the research, based on MESH/DeCS with the following terms "local anesthetics, healing, neovascularization, collagen" with AND or OR search, considering the title and/or abstract. Next, only those that were most related to the topic were included, and the texts were read for inclusion.Results:
73 articles were included, read and interpreted focusing on the role of anesthetics in healing, pain, side effects and the best that currently emerge in analgesia and scar potential.Conclusions:
No differences were observed between the anesthetics studied in terms of healing, inflammation and neovascularization. However, there was a significant difference in the production of collagens with an intensity of 6 to 12 times greater than collagen types I, II and III with the use of levobupivacaine.RESUMO
Introdução:
Avaliar as diferenças cicatriciais entre áreas previamente anestesiadas com diferentes anestésicos locais é interessante para verificar se a escolha do anestésico auxilia na cicatrização cirúrgica em relação à inflamação, neovascularização e deposição de colágeno.Objetivos:
Revisar a literatura existente com foco de análise sobre o papel dos anestésicos locais no auxílio da cicatrização de feridas cirúrgicas.Método:
Revisão narrativa da literatura selecionada das plataformas SciELO Scientific Electronic Library Online, Google Scholar, Pubmed e Scopus. Inicialmente a revisão realizou a busca por palavras-chave no foco da pesquisa, com base no MESH/DeCS com os seguintes termos "anestésicos locais, cicatrização, neovascularização, colágeno" com busca AND ou OR, considerando o título e/ou resumo. A seguir, foram incluídos somente os que tinham maior relação ao tema, e realizada a leitura dos textos para inclusão.Resultados:
Foram incluídos, lidos e interpretados 73 artigos enfocando o papel dos anestésicos na cicatrização, dor, efeitos colaterais e os melhores que despontam na atualidade na analgesia e potencial cicatricial.Conclusões:
Não se observou diferenças entre anestésicos pesquisados quanto à cicatrização, inflamação e neovascularização. Contudo, verificou-se diferença significativa na produção de colágenos com intensidade de 6 a 12 vezes maior de colágenos tipos I, II e III com o uso da levobupivacaína.
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Collection:
Preprints
Database:
SciELO Preprints
Language:
Portuguese
Year:
2024
Document type:
Preprint