Apolipoprotein B gene polymorphisms in people in the East Mediterranean area of Turkey
(East. Mediterr. health j).
in En
| WHOLIS
| ID: who-119390
Responsible library:
CH1.1
ABSTRACT
Point mutations in the receptor binding domain of low density lipoprotein may increase cholesterol levels in blood. Three mutations of Apo B-100 protein result in defective binding [Arg 3500 ----> [corrected] Gln, Arg 3500 ----> [corrected] Trp and Arg 3531 ----> [corrected] Cys]. We estimated the frequency of Apo B point mutations [codon 3500] C9774T [Arg 3500 ----> [corrected] Trp] and G9775A [Arg 3500 ----> [corrected] Gln] in 179 atherosclerotic, 145 hyperlipidaemic individuals and 272 healthy individuals in the east Mediterranean region of Turkey. Lipid and lipoprotein levels were measured with routine biochemical analyser and Apo B mutation was detected using real-time PCR. Neither mutation was found. In this region, Apo B-100 protein mutations are rare and causes of hyperlipidaemia and atherosclerosis may therefore be unrelated to them
Key words
Full text:
1
Collection:
04-international_org
Database:
WHOLIS
Main subject:
Apolipoproteins A
/
Apolipoproteins B
/
Arteriosclerosis
/
Case-Control Studies
/
Causality
/
Rare Diseases
/
Apolipoprotein B-100
/
Gene Frequency
/
Cholesterol, HDL
Language:
En
Journal:
East. Mediterr. health j
Year:
2004