Risk Factors for Cognitive Impairment after Acute Ischemic Stroke / 中风与神经疾病杂志

ABSTRACT

@#Objective To illustrate the occurrence of cognitive impairment in patients with acute ischemic stroke and analyze its risk factors. Methods According to the inclusion and exclusion criteria,104 patients with acute ischemic stroke who were hospitalized in Renmin Hospital of Wuhan University from July 2017 to August 2018 were continuously collected. The patients were divided into post-stroke cognitive impairment group (PSCI) and post-stroke cognitive normal group (PSCN) based on their performance on MMSE. General demographic,biochemical and stroke information were compared between the two groups. Results 41 cases out of 104 patients with acute ischemic stroke showed cognitive impairment. The incidence rate was 39.4%. Univariate analysis showed statistically significant differences in age,hs-CRP,and cerebral hemisphere lesions between the two groups of patients (P<0.05). The location of the lesion in the basal ganglia may be related to cognitive impairment (P=0.057). Multivariate logistic regression analysis showed that compared with the PSCN group,patients in the PSCI group were older (OR=1.087),and the incidence of basal ganglia lesions was higher (OR=3.935). The difference between the two groups was statistically significant (P<0.05). Conclusion The incidence of cognitive impairment is higher in patients with acute ischemic stroke. Older age and basal ganglia lesions are independent risk factors for cognitive impairment after stroke.