The variation of thiodiglycolic acid concentration in urine with vinyl chloride exposure levels in rats / 대한산업의학회지
Korean Journal of Occupational and Environmental Medicine
; : 431-438, 1999.
Article
in Ko
| WPRIM
| ID: wpr-119575
Responsible library:
WPRO
ABSTRACT
OBJECTIVES: It is the objective of this research to identify the variation of thiodiglycolic acid (TdGA) in urine with vinyl chloride monomer (VCM) exposure levels through methylation. METHODS: After rats were exposed to vinyl chloride monomer of 4 levels, 0 mg/m3, 50 mg /m3, 150 mg/m3, 500 mg/m3, respectively, of which urine was sampled in each sampling time of 0 hour, 2 hours, 4 hours, 8 hours, 16 hours, 24 hours, 36 hours, 48 hours. After urine had been methylated with diazomethane in the preliminary experiment and the peak of 146 m/z had been verified, the main experiment was done. RESULTS: In the variation of TdGA with sampling times, concentration of TdGA increased rapidly in 4 hours and then decreased after 8 hours. When the variation of urinary .TdGA concentration in urine according to exposure level of VCM was verified through Kruskal-Wallis statistical method at each sampling time, the significant increment with the exposure levels at 2 hours, 4 hours, 8 hours after exposure was clarified. CONCLUSION: TdGA concentration in urine with increment of VCM exposure level increased, especially significantly at 2 hours, 4 hours, 8 hours of sampling time.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Vinyl Chloride
/
Diazomethane
/
Methylation
Limits:
Animals
Language:
Ko
Journal:
Korean Journal of Occupational and Environmental Medicine
Year:
1999
Document type:
Article