A Case of Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin / 대한피부과학회지
Korean Journal of Dermatology
; : 350-352, 2006.
Article
in Ko
| WPRIM
| ID: wpr-136887
Responsible library:
WPRO
ABSTRACT
Toxic epidermal necrolysis (TEN) is a rare, life-threatening, mucocutaneous drug reaction, which causes extensive epidermal detachment and serious complications involving ocular structures and internal organs. Recently, intravenous immunoglobulin (IVIG) was suggested to be effective in treating TEN through the blockage of Fas receptors which initiate keratinocyte apoptosis. Herein, we tried IVIG teratment (0.6 g/kg/day for 4 consecutive days) for a case of TEN. As a result, the progression of epidermal detachment was interrupted within 2 days and epithelialization was completed in 3 weeks without significant side effects.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Immunoglobulins
/
Keratinocytes
/
Stevens-Johnson Syndrome
/
Immunoglobulins, Intravenous
/
Apoptosis
/
Fas Receptor
Language:
Ko
Journal:
Korean Journal of Dermatology
Year:
2006
Document type:
Article