A Case of CD3O-negative Large T-Cell Lymphoma Showing p53 and mdm-2 Expression / 대한피부과학회지
Korean Journal of Dermatology
; : 688-693, 1998.
Article
in Ko
| WPRIM
| ID: wpr-150045
Responsible library:
WPRO
ABSTRACT
Primary cutaneous large cell lymphomas of the T-cell phenotype are relatively uncommon. Previous studies have revealed the following prognostic variables: the distribution of skin lesions, a history of pre-existing mycosis fungoides, CD30(Ki-1) antigen positivity and anaplastic morphology. CD30 antigen positivity has been associated with an indolent clinical course, in contrast to CD30-negative cases. However, a recent study revealed that multicentric skin lesions confer a worse prognosis on this subgroup of patients rather than the absence of CD30 antigen. p53 immunoreactivity also has been reported to be associated with high grade non-Hodgkin's lymphoma, although it is relatively uncommon. Herein, we report a case of a patient with EBV-related, CD30-negative primary cutaneous large cell lymphoma of the T-cell phenotype showing p53 and mdm-2 expression. She was initially diagnosed as having a benign-looking deep folliculitis or furunculosis, but treated successfully with radiation therapy without recurrence up to now.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Phenotype
/
Prognosis
/
Recurrence
/
Skin
/
Lymphoma, Non-Hodgkin
/
T-Lymphocytes
/
Lymphoma, T-Cell
/
Mycosis Fungoides
/
Ki-1 Antigen
/
Folliculitis
Type of study:
Clinical_trials
/
Prognostic_studies
Limits:
Humans
Language:
Ko
Journal:
Korean Journal of Dermatology
Year:
1998
Document type:
Article