Transient improvement of pyruvate metabolism after coenzyme Q therapy in Kearns-Sayre syndrome: MRS study
Yonsei Medical Journal
; : 676-679, 2000.
Article
in En
| WPRIM
| ID: wpr-202103
Responsible library:
WPRO
ABSTRACT
Coenzyme Q therapy has been used to support metabolic derangements in patients with mitochondrial encephalomyopathies. Biochemical analysis of the living human brain can be performed by magnetic resonance spectroscopy (MRS). We report upon a KSS patient who was serially imaged with localized proton MRS to monitor the efficacy of CoQ treatment. A 17-year-old girl with KSS was serially imaged with localized proton MRS performed on a GE 1.5 T SIGNA MRI/MRS system. The elevated lactate contents of lesions decreased after one month of CoQ therapy but were re-elevated 10 months after treatment. We conclude that MRS presents us with a powerful tool for monitoring the effects of therapeutic trials in mitochondrial encephalomyopathies.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Brain
/
Magnetic Resonance Spectroscopy
/
Kearns-Sayre Syndrome
/
Adolescent
/
Ubiquinone
/
Treatment Outcome
/
Lactic Acid
/
Pyruvic Acid
Limits:
Female
/
Humans
Language:
En
Journal:
Yonsei Medical Journal
Year:
2000
Document type:
Article