Prevalence of Primary Immunodeficiency in Korea
Journal of Korean Medical Science
; : 788-793, 2012.
Article
in En
| WPRIM
| ID: wpr-210927
Responsible library:
WPRO
ABSTRACT
This study represents the first epidemiological study based on the national registry of primary immunodeficiencies (PID) in Korea. Patient data were collected from 23 major hospitals. A total of 152 patients with PID (under 19 yr of age), who were observed from 2001 to 2005, have been entered in this registry. The period prevalence of PID in Korea in 2005 is 11.25 per million children. The following frequencies were found: antibody deficiencies, 53.3% (n = 81), phagocytic disorders, 28.9% (n = 44); combined immunodeficiencies, 13.2% (n = 20); and T cell deficiencies, 4.6% (n = 7). Congenital agammaglobulinemia (n = 21) and selective IgA deficiency (n = 21) were the most frequently reported antibody deficiency. Other reported deficiencies were common variable immunodeficiencies (n = 16), X-linked agammaglobulinemia (n = 15), IgG subclass deficiency (n = 4). Phagocytic disorder was mostly chronic granulomatous disease. A small number of patients with Wiskott-Aldrich syndrome, hyper-IgE syndrome, and severe combined immunodeficiency were also registered. Overall, the most common first manifestation was pneumonia. This study provides data that permit a more accurate estimation PID patients in Korea.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Wiskott-Aldrich Syndrome
/
Registries
/
Prevalence
/
Surveys and Questionnaires
/
Severe Combined Immunodeficiency
/
IgG Deficiency
/
IgA Deficiency
/
Common Variable Immunodeficiency
/
Sex Distribution
/
Age Distribution
Type of study:
Prevalence_studies
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Newborn
Country/Region as subject:
Asia
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2012
Document type:
Article