Association of-238G/A and -857C/T polymorphisms of tumor necrosis factor-alpha gene promoter region with outcomes of hepatitis B virus infection / 生物医学与环境科学(英文)
Biomed. environ. sci
; Biomed. environ. sci;(12): 133-136, 2006.
Article
in En
| WPRIM
| ID: wpr-229714
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVES</b>To determine whether -238G/A and -857C/T polymorphisms of tumor necrosis factor-alpha (TNF-alpha) gene promoter were associated with outcomes of hepatitis B virus infection.</p><p><b>METHODS</b>A total of 246 HBV self-limited infected subjects and 443 chronic hepatitis B (HB) patients were recruited in this case-control study. TNF-alpha-238G/A and -857C/T gene promoter polymorphisms were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).</p><p><b>RESULTS</b>The frequency of TNF-alpha-238 GG (90.7%) in chronic HB group was significantly lower than that (95.1%) in self-limited group (P = 0.041). The frequency of TNF-alpha-857 CC (79.7%) in chronic HB patients was significantly higher than that (70.9%) in self-limited infected subjects (P = 0.021). Multiple logistic regression analysis revealed that both TNF-alpha-238GA and -857CC were independently associated with chronic HB.</p><p><b>CONCLUSIONS</b>TNF-alpha promoter variants are likely to play a substantial role in influencing the outcomes of HBV infection.</p>
Full text:
1
Database:
WPRIM
Main subject:
Polymorphism, Genetic
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Virulence
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Haplotypes
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Polymorphism, Restriction Fragment Length
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Case-Control Studies
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Hepatitis B virus
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Polymerase Chain Reaction
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Promoter Regions, Genetic
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Tumor Necrosis Factor-alpha
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Hepatitis B, Chronic
Type of study:
Observational_studies
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Risk_factors_studies
Limits:
Adult
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Female
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Humans
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Male
Language:
En
Journal:
Biomed. environ. sci
Year:
2006
Document type:
Article