Adjuvant chemotherapy for gastric cancer: more drugs do not mean better efficacy / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 432-435, 2011.
Article
in Zh
| WPRIM
| ID: wpr-237103
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare oncologic outcomes between doublet and triplet adjuvant chemotherapy for gastric cancer patients undergoing radical resection.</p><p><b>METHODS</b>Patients with gastric cancer receiving adjuvant chemotherapy after radical resection from January 2004 to December 2008 were included. Doublet was defined as 5-FU 750 mg/m² (days 1-5) or capecitabine 1000 mg/m² (days 1-14) plus cisplatin 60 mg/m² (day 1) or oxaliplatin 130 mg/m² (day 1), while triplets had epirubicin 50 mg/m² (day 1) added. Chemotherapy was initiated 4-6 weeks after surgery, repeated every three weeks for 6 cycles. Patients were followed-up in the outpatient clinic until death or the most recent follow up(April 30, 2010). Cox proportional- hazard model and Chi-square test were used to test statistical difference.</p><p><b>RESULTS</b>A total of 316 patients (210 received doublets, 106 received triplets) had a median follow-up time of 47 months. Seventy-seven patients died at the end of the follow-up. Two groups were comparable except for age (median age of 57 in doublets, 51 in triplets, P<0.01). The two groups had similar disease-free survival (16 months vs. 23 months, P=0.656) and 3-year overall survival(59.6% vs. 64.8%, P=0.293). There was no significant difference in severe adverse side effects between the two groups (21.9% vs. 30.2%, P=0.107).</p><p><b>CONCLUSION</b>Triplet adjuvant chemotherapy appears not to be associated with superior efficacy than doublet regimen for patients with gastric cancer after radical resection.</p>
Full text:
1
Database:
WPRIM
Main subject:
Postoperative Care
/
Prognosis
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Stomach Neoplasms
/
Retrospective Studies
/
Cisplatin
/
Chemotherapy, Adjuvant
/
Deoxycytidine
/
Drug Therapy
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Capecitabine
/
Fluorouracil
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Female
/
Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2011
Document type:
Article