Expression of CD147, matrix metalloproteinases and transforming growth factor beta1 in breast cancer / 中华病理学杂志
Chinese Journal of Pathology
; (12): 524-528, 2009.
Article
in Zh
| WPRIM
| ID: wpr-249091
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of CD147, matrix metalloproteinase (MMP)-2, MMP-9, Transforming growth factor (TGFbeta1) and TGFbetaRI proteins and their relationships to breast cancer.</p><p><b>METHODS</b>The expression of CD147, MMP-2, MMP-9, TGFbeta1 and TGFbetaRI proteins was examined on tissue chips containing 160 cases of breast carcinomas by S-P immunohistochemical method.</p><p><b>RESULTS</b>The positive rates of CD147, MMP-2, MMP-9, TGFbeta1 and TGFbetaRI proteins were 87.5% (140/160), 96.9% (155/160), 95.0% (152/160), 73.7% (118/160) and 60.6% (97/160), respectively. The expression of CD147 was positively correlated with axillary lymph node metastasis, TNM staging and HER2 over expression (P < 0.01, P < 0.05 and P < 0.01, respectively), and inversely correlated with PR expression (P < 0.05). The patients' relapse-free survival was shorter in TGFbeta1-positive group than in TGFbeta1 negative group (P < 0.05). Both the expression of MMP-2 and MMP-9 were positively correlated with CD147 expression; and both the expression of TGFbeta1 and TGFbetaRI were positively correlated with CD147 expression (P < 0.01 and P < 0.05, respectively).</p><p><b>CONCLUSION</b>The expression of CD147 is considered closely correlated with tumor invasion, metastasis and prognosis in breast cancer, and has also a close correlation with MMP-2, MMP-9, TGFbeta1 and TGFbetaRI expression.</p>
Full text:
1
Database:
WPRIM
Main subject:
Pathology
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Breast Neoplasms
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Receptors, Progesterone
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Survival Rate
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Follow-Up Studies
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Protein Serine-Threonine Kinases
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Receptors, Transforming Growth Factor beta
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Fibroadenoma
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Carcinoma, Ductal, Breast
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Receptor, ErbB-2
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Adult
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Aged
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Female
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Humans
Language:
Zh
Journal:
Chinese Journal of Pathology
Year:
2009
Document type:
Article