Research on application of determination of MMP-13 in osteoarthritis / 中国骨伤
China Journal of Orthopaedics and Traumatology
; (12): 617-620, 2014.
Article
in Zh
| WPRIM
| ID: wpr-249304
Responsible library:
WPRO
ABSTRACT
Osteoarthritis (OA) is a complex chronic progressive disease attacked by biological and mechanical factors and a result from the anabolic and catabolic imbalance in chondrocyte, subchondral bone and extracellular matrix(ECM). Etiology and pathological of OA are not yet entirely clear. The degradation and destruction of collagen II caused by matrix metalloproteinase -13 (MMP-13) is considered the core factor in the occurrence and development of OA. The research of MMP-13 inhibitor provide ideas and methods for the treatment of OA. In this article,the role and determination of MMP-13 in OA and the development prospect of MMP-13 inhibitor in the treatment of OA research progress were reviewed.
Full text:
1
Database:
WPRIM
Main subject:
Osteoarthritis
/
Physiology
/
Collagen
/
Therapeutic Uses
/
Drug Therapy
/
Matrix Metalloproteinase 13
/
Matrix Metalloproteinase Inhibitors
/
Metabolism
Limits:
Animals
/
Humans
Language:
Zh
Journal:
China Journal of Orthopaedics and Traumatology
Year:
2014
Document type:
Article