Alkaline-degradation products of ginsenosides from leaves and stems of Panax quinquefolium / 药学学报
Acta Pharmaceutica Sinica
; (12): 924-930, 2005.
Article
in Zh
| WPRIM
| ID: wpr-253539
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To study the alkaline-degradation products of ginsenosides from leaves and stems of Panax quinquefolium L.</p><p><b>METHODS</b>Isolation and purification were carried out on silica gel and HPLC; the structures of chemical constituents were elucidated by spectral analysis.</p><p><b>RESULTS</b>From the alkaline-degradation products, nine compounds were identified as: 20 (S) -protopanaxadiol (I), 20 (S) -dammar-25 (26)-ene-3beta, 12beta, 20-triol (II), 24 (R) -ocotillol (III), 20 (S) -protopanaxatriol (IV), 20 (S) -dammar-25 (26)-ene-3beta, 6alpha, 12beta, 20-tetrol (V), dammar-20 (21), 24-diene-3beta, 12beta-diol (VI), dammar-20(21), 24-diene-3beta, 6alpha, 12beta-triol (VII), 20 (S), 24 (S) -dammar-25 (26) -ene-3beta, 6alpha, 12beta, 20, 24-pentanol (VIII), 20 (S) -dammar-23-ene-25-hydroperoxyl-3beta, 6alpha, 12beta, 20-tetrol (IX).</p><p><b>CONCLUSION</b>The configuration of C20 position of ginsenosides was not changed by alkaline-degradation. The complete assignments of 1H and 13C NMR chemical shifts of four new compounds V, VII, VIII, IX, were acquired by means of 2D NMR spectra. Compound I showed antitumor effect on human colon carcinoma cells in vitro.</p>
Full text:
1
Database:
WPRIM
Main subject:
Pathology
/
Pharmacology
/
Plants, Medicinal
/
Sapogenins
/
Triterpenes
/
Molecular Structure
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Chemistry
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Colonic Neoplasms
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Plant Stems
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Plant Leaves
Limits:
Humans
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2005
Document type:
Article