Progress on association between low-density lipoprotein receptor and metabolic syndrome / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 101-107, 2015.
Article
in Zh
| WPRIM
| ID: wpr-255226
Responsible library:
WPRO
ABSTRACT
Low-density lipoprotein receptor (LDLR) and metabolic syndrome (MS) are closely correlated. Changes in LDLR expression, feedback regulation and degradation, impacts of LDLR deficiency on blood lipid levels, roles of LDLR in islet β cell dysfunction and cholesterol homeostasis dysregulation, expression of LDLR gene nuclear transcription factors and polymorphism of LDLR gene segments are all involved in the development of specific components of MS. In recent years, a variety of targets and intervention mechanisms in relation to LDLR and MS have been extensively studied. Knowledge about association between LDLR and MS may contribute to the development of strategies for prevention and treatment of MS. This article reviews the update on the association between LDLR and MS.
Full text:
1
Database:
WPRIM
Main subject:
Receptors, LDL
/
Metabolic Syndrome
/
Lipid Metabolism
/
Homeostasis
/
Lipoproteins, LDL
Limits:
Humans
Language:
Zh
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2015
Document type:
Article
Publication country:
CHINA
/
CN
/
REPUBLIC OF CHINA