Unique interactions between scorpion toxins and small conductance Ca(2+)-activated potassium channels / 生理学报
Acta Physiologica Sinica
; (6): 255-260, 2015.
Article
in En
| WPRIM
| ID: wpr-255950
Responsible library:
WPRO
ABSTRACT
Small conductance Ca(2+)-activated potassium channels (SK channels) distributing in the nervous system play an important role in learning, memory and synaptic plasticity. Most pharmacological properties of them are determined by short-chain scorpion toxins. Different from most voltage-gated potassium channels and large-conductance Ca(2+)-activated potassium channels, SK channels are only inhibited by a small quantity of scorpion toxins. Recently, a novel peptide screener in the extracellular pore entryway of SK channels was considered as the structural basis of toxin selective recognition. In this review, we summarized the unique interactions between scorpion toxins and SK channels, which is crucial not only in deep-researching for physiological function of SK channels, but also in developing drugs for SK channel-related diseases.
Full text:
1
Database:
WPRIM
Main subject:
Scorpion Venoms
/
Scorpions
/
Chemistry
/
Small-Conductance Calcium-Activated Potassium Channels
/
Memory
/
Neuronal Plasticity
Limits:
Animals
Language:
En
Journal:
Acta Physiologica Sinica
Year:
2015
Document type:
Article