A case of severe hyponatremia induced by duloxetine and ziprasidone / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 3750-3751, 2012.
Article
in En
| WPRIM
| ID: wpr-256653
Responsible library:
WPRO
ABSTRACT
We report a case of severe hyponatremia related to duloxetine and ziprasidone. A 50-year-old woman on duloxetine and ziprasidone treatment for major depressive disorder developed polydipsia, polyuria, and two episodes of seizures, followed by admission to the emergency department on the 10th day of treatment. Laboratory investigations revealed elevated creatine kinase (CK) as well as hyponatremia, hypo-osmolality, and increased urine sodium. Syndrome of Inappropriate Antidiuretic Hormone (SIADH) was considered, although urine osmolality was not measured. Duloxetine and ziprasidone were discontinued and the CK gradually normalized after correction of hyponatremia. Clinicians should be aware of the possibility of antipsychotic-induced hyponatremia, particularly in patients with symptoms of polydipsia.
Full text:
1
Database:
WPRIM
Main subject:
Piperazines
/
Thiazoles
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Thiophenes
/
Antipsychotic Agents
/
Blood
/
Creatine Kinase
/
Depressive Disorder, Major
/
Drug Therapy
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Duloxetine Hydrochloride
/
Hyponatremia
Limits:
Female
/
Humans
Language:
En
Journal:
Chinese Medical Journal
Year:
2012
Document type:
Article