Research progress of the drug delivery system of antitumor platinum drugs with macrocyclic compounds / 药学学报
Acta Pharmaceutica Sinica
; (12): 650-657, 2015.
Article
in Zh
| WPRIM
| ID: wpr-257087
Responsible library:
WPRO
ABSTRACT
Platinum-based anticancer drugs have been becoming one of the most effective drugs for clinical treatment of malignant tumors for its unique mechanism of action and broad range of anticancer spectrum. But, there are still several problems such as side effects, drug resistance/cross resistance and no-specific targeting, becoming obstacles to restrict its expanding of clinical application. In recent years, supramolecular chemistry drug delivery systems have been gradually concerned for their favorable safety and low toxicity. Supramolecular macrocycles-platinum complexes increased the water solubility, stability and safety of traditional platinum drugs, and have become hot focus of developing novel platinum-based anticancer drugs because of its potential targeting of tumor tissues/organs. This article concentrates in the research progress of the new drug delivery system between platinum-based anticancer drugs with three generations of macrocycles crown ether, cyclodextrin, cucurbituril and calixarene.
Full text:
1
Database:
WPRIM
Main subject:
Pharmacology
/
Drug Delivery Systems
/
Platinum Compounds
/
Cyclodextrins
/
Macrocyclic Compounds
/
Calixarenes
/
Crown Compounds
/
Drug Therapy
/
Neoplasms
/
Antineoplastic Agents
Limits:
Humans
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2015
Document type:
Article
Publication country:
CHINA
/
CN
/
REPUBLIC OF CHINA