Optimize dropping process of Ginkgo biloba dropping pills by using design space approach / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2479-2483, 2017.
Article
in Zh
| WPRIM
| ID: wpr-258491
Responsible library:
WPRO
ABSTRACT
In this paper, a design space approach was applied to optimize the dropping process of Ginkgo biloba dropping pills. Firstly, potential critical process parameters and potential process critical quality attributes were determined through literature research and pre-experiments. Secondly, experiments were carried out according to Box-Behnken design. Then the critical process parameters and critical quality attributes were determined based on the experimental results. Thirdly, second-order polynomial models were used to describe the quantitative relationships between critical process parameters and critical quality attributes. Finally, a probability-based design space was calculated and verified. The verification results showed that efficient production of Ginkgo biloba dropping pills can be guaranteed by operating within the design space parameters. The recommended operation ranges for the critical dropping process parameters of Ginkgo biloba dropping pills were as follows: dropping distance of 5.5-6.7 cm, and dropping speed of 59-60 drops per minute, providing a reference for industrial production of Ginkgo biloba dropping pills.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2017
Document type:
Article