Influence of HLA-G on immunoregulatory function of human amniotic mesenchymal cells / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1325-1328, 2011.
Article
in Zh
| WPRIM
| ID: wpr-261875
Responsible library:
WPRO
ABSTRACT
Human leukocyte antigen G (HLA-G), a kind of non-classical major histocompatibility complex class I antigens, can inhibit inflammatory reaction, assist tumor cells to escape from immune surveillance and promote the immunologic tolerance of the graft. HLA-G, expressed and secreted by human amniotic mesenchymal cells (HAMC), suppresses the functions of NK cells, T cells and B cells and modulates the activity of dendritic cells (DC). These findings provide a theoretical basis for illustrating the mechanism of immunosuppression on HAMC. In this article, the recent advances on not only the gene and the molecular structure of HLA-G, but also the possible mechanisms of HLA-G in immunoregulatory function of HAMC, as well as the relation of HLA-G with HAMC, NK, DC, T and B cells are reviewed.
Full text:
1
Database:
WPRIM
Main subject:
Cell Biology
/
Allergy and Immunology
/
Mesenchymal Stem Cells
/
HLA-G Antigens
/
Amnion
/
Immune Tolerance
Limits:
Humans
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2011
Document type:
Article