A linkage between beta-fibrinogen gene -148C/T polymorphism and cerebral infarction / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 202-204, 2006.
Article
in Zh
| WPRIM
| ID: wpr-263817
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the linkage between -148C/T polymorphism of beta-fibrinogen gene and plasma fibrinogen levels in patients with acute cerebral infarction.</p><p><b>METHODS</b>One hundred and fifty-one patients with cerebral infarction and 101 healthy individuals were enrolled in this trial. The beta-fibrinogen gene -148C/T polymorphism was analyzed by PCR-restriction fragment length polymorphism, and plasma fibrinogen levels were obtained from prothrombin time assay.</p><p><b>RESULTS</b>Plasma fibrinogen levels of patients were significantly higher than those of controls (P<0.01). In both groups, T allele carriers had higher plasma fibrinogen levels than other those did (P<0.01); and the fibrinogen level difference was still significant if both groups was based on their sex (P<0.05). Divided by age, each group of the study cases has significant difference between two genotypes (P<0.05). T -148 allele frequency of the middle age case in study group was higher than that in control group (P<0.05).</p><p><b>CONCLUSION</b>High plasma fibrinogen level is a risk factor to cerebral infarction. Plasma fibrinogen level is affected by -148C/T polymorphism of beta-fibrinogen gene. With or without other risk factors and environmental factors affecting, T allele increases plasma fibrinogen level and may be a heritable risk factor to cerebral infarction.</p>
Full text:
1
Database:
WPRIM
Main subject:
Polymorphism, Genetic
/
Fibrinogen
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Cerebral Infarction
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Genetic Predisposition to Disease
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Stroke
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Asian People
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Alleles
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Genetics
Limits:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Medical Genetics
Year:
2006
Document type:
Article