Effects of aqueous extract in herba of Lysimachia christinae on hyperuricemia in mice / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 939-944, 2002.
Article
in Zh
| WPRIM
| ID: wpr-271834
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study hypouricemic effect of aqueous extract of Lysimachia christinae on hyperuricemia in mice.</p><p><b>METHOD</b>The uricase inhibitor potassium oxonate was used to induce hyperuricemia in mice, and serum uric acid level was determined with the phosphotungstic acid method.</p><p><b>RESULT</b>The aqueous extract of Lysimachia christinae, when administered orally to the oxonate-induced hyperuricemic mice at the doses of 5.2, 10.4 and 20.8 g.kg-1, was able to elicit dose-dependent hypouricemic effects. At these doses of the extract, the serum urate levels of the oxonate-pretreated mice showed no difference from the normal mice. In normal mice, however, oral administration of the extract at the same doses did not produce any observable hypouricemic effects.</p><p><b>CONCLUSION</b>The aqueous extract of Lysimachia christinae possesses potent hypuricemic effects on models of hyperuricemia in mice pretreated with oxonate.</p>
Full text:
1
Database:
WPRIM
Main subject:
Pharmacology
/
Plants, Medicinal
/
Uric Acid
/
Blood
/
Drugs, Chinese Herbal
/
Chemistry
/
Primulaceae
/
Hyperuricemia
Limits:
Animals
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2002
Document type:
Article