The assessment of hemoperfusion for the treatment of acute methamidophos poisoning / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
; (12): 440-442, 2011.
Article
in Zh
| WPRIM
| ID: wpr-272571
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effect of hemoperfusion(HP) about the patients of methamidophos poisoning.</p><p><b>METHODS</b>On the basis of comprehensive treatment,15 cases of severe acute methamidophos poisoning patients were treated with HP, Blood samples were collected at 7 time points, before and 5, 15, 30, 45, 60mins following the beginning and the end of hemoperfusion. Blood samples were used for measuring the concentration of methamidophos and perfusion devices were used for measuring the volume of methamidophos adsorbed by the device after hemoperfusion.</p><p><b>RESULTS</b>15 patients live in 12 cases, 3 cases of death. HP (former) blood Cholinesterase vigor were 662.60 + 632.05, HP (after) blood cholinesterase vigor were 2577.52 + 920.38 IU/L; The difference of blood Cholinesterase vigor between the before and after HP was statistically significant (P < 0.01). The patients' methamidophos concentration of blood when HP treated 45, 60, 120 min were respectively (851 + 672), (680 + 529), (587 + 520) microg /ml, there were significantly lower than that the patients' methamidophos concentration of blood who were before HP (1659 + 1105) microg/ml, a statistically significant difference (P < 0.01).</p><p><b>CONCLUSION</b>HP can be cut down obviously methamidophos poisoning patients serum concentrations of toxic, the experimental method directly prove the clinical application of carbon HP can really adsorption methamidophos.</p>
Full text:
1
Database:
WPRIM
Main subject:
Organothiophosphorus Compounds
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Poisoning
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Cholinesterases
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Hemoperfusion
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Treatment Outcome
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Insecticides
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Metabolism
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Methods
Limits:
Adult
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Year:
2011
Document type:
Article