Progress in small-molecule inhibitors of Bcl-2 family proteins / 药学学报
Acta Pharmaceutica Sinica
; (12): 669-677, 2008.
Article
in Zh
| WPRIM
| ID: wpr-277814
Responsible library:
WPRO
ABSTRACT
Apoptosis is an essential factor in keeping homeostasis of the organism. Apoptosis is regulated by a series of cytokines. Bcl-2 family proteins are key regulators of apoptosis. The Bcl-2 family includes both anti- and pro-apoptotic proteins with opposing biological functions. Their interaction regulates the transmission of the apoptosis signal. High expression of anti-apoptotic members such as Bcl-2 and Bcl-xL are commonly found in human cancers. In recent years, following the disclosing of the crystal structures of Bcl-2 family proteins, researchers have paid attention to the development of the small molecule inhibitors of Bcl-2 family proteins. This article reviews the progress in this field from the view of drug design.
Full text:
1
Database:
WPRIM
Main subject:
Pharmacology
/
Piperazines
/
Structure-Activity Relationship
/
Sulfonamides
/
Thiazoles
/
Benzopyrans
/
Biphenyl Compounds
/
Gossypol
/
Drugs, Chinese Herbal
/
Drug Design
Type of study:
Prognostic_studies
Limits:
Humans
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Document type:
Article