Role of PKCbeta in the malignant tumors and enzastaurin, a PKCbeta inhibitor / 药学学报
Acta Pharmaceutica Sinica
; (12): 449-455, 2009.
Article
in Zh
| WPRIM
| ID: wpr-278240
Responsible library:
WPRO
ABSTRACT
Protein kinase C beta (PKCbeta) is a multifunctional serine/threonine protein kinase, which plays an important role in many cell signaling pathways. PKCbeta takes part in multiple physiological processes, including regulation of the cell cycle, differentiation, proliferation, apoptosis and angiogenesis. Increased PKCbeta activity has been observed in many human cancers, such as colon, breast and haematological malignancies. At present, Enzastaurin is mostly studied in preclinical and clinical studies, which is a selective PKCbeta inhibitor. This review focuses on the functional properties of PKCbeta, its role played in tumors and Enzastaurin.
Full text:
1
Database:
WPRIM
Main subject:
Pathology
/
Pharmacology
/
Protein Kinase C
/
Chemistry
/
Clinical Trials as Topic
/
Cell Line, Tumor
/
Therapeutic Uses
/
Protein Kinase Inhibitors
/
Cell Proliferation
/
Drug Therapy
Limits:
Animals
/
Humans
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2009
Document type:
Article