Application of the Oxford classification of IgA nephropathy to predict renal outcome / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 102-107, 2013.
Article
in Zh
| WPRIM
| ID: wpr-284296
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To validate the value of the Oxford classification of IgA nephropathy in predicting the renal outcome in Chinese population.</p><p><b>METHODS</b>Retrospective study was done in patients with IgA nephropathy. All slides were re-assessed according to the Oxford classification of IgA nephropathy. The primary end point is doubling serum creatinine, or a 50% reduction in estimated glomerular filtration rate (eGFR), or end-stage renal disease. Pathologic predictors for the progression to the end point were determined by univariate and multivariate Cox regression.</p><p><b>RESULTS</b>Totally 533 patients were enrolled in the study. During the follow-up (median 39 months; range 12-263 months), 5.07% of the patients reached the end point. While tubular atrophy and interstitial fibrosis and arterial/ arteriolar lesion were associated with the endpoint in univariate analysis, only the T score was predictive of the renal outcome in multivariate Cox regression. Combination of the patho- logic lesions had no impact on renal outcome.</p><p><b>CONCLUSION</b>According to the Oxford classification of IgA nephropathy, the degree of tubulointerstitial fibrosis is the only feature independently predictive of renal outcome.</p>
Full text:
1
Database:
WPRIM
Main subject:
Pathology
/
Prognosis
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Retrospective Studies
/
Follow-Up Studies
/
Classification
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Glomerulonephritis, IGA
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Kidney
Type of study:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limits:
Adolescent
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Adult
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Aged
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Female
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Humans
/
Male
Language:
Zh
Journal:
Acta Academiae Medicinae Sinicae
Year:
2013
Document type:
Article
Country of publication:
CHINA
/
CN
/
REPUBLIC OF CHINA