Application of the Oxford classification of IgA nephropathy to predict renal outcome / 中国医学科学院学报

ABSTRACT

<p><b>OBJECTIVE</b>To validate the value of the Oxford classification of IgA nephropathy in predicting the renal outcome in Chinese population.</p><p><b>METHODS</b>Retrospective study was done in patients with IgA nephropathy. All slides were re-assessed according to the Oxford classification of IgA nephropathy. The primary end point is doubling serum creatinine, or a 50% reduction in estimated glomerular filtration rate (eGFR), or end-stage renal disease. Pathologic predictors for the progression to the end point were determined by univariate and multivariate Cox regression.</p><p><b>RESULTS</b>Totally 533 patients were enrolled in the study. During the follow-up (median 39 months; range 12-263 months), 5.07% of the patients reached the end point. While tubular atrophy and interstitial fibrosis and arterial/ arteriolar lesion were associated with the endpoint in univariate analysis, only the T score was predictive of the renal outcome in multivariate Cox regression. Combination of the patho- logic lesions had no impact on renal outcome.</p><p><b>CONCLUSION</b>According to the Oxford classification of IgA nephropathy, the degree of tubulointerstitial fibrosis is the only feature independently predictive of renal outcome.</p>