The relationship between nonresponse to hepatitis B vaccine and HLA genotype/haplotype / 中华预防医学杂志
Chinese Journal of Preventive Medicine
; (12): 180-183, 2002.
Article
in En
| WPRIM
| ID: wpr-295776
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between the nonresponse to hepatitis B vaccine and HLA genotype/heplotype in Chinese population and provide the evidence for explaining the genetic mechanism of this nonresponse.</p><p><b>METHODS</b>Our research focused on the relationship between nonresponse to Hepatitis B vaccine and HLA-DRB1, DRB3, DRB4, DRB5 and DQB1 genotype/haplotype in Chinese population, collected from a community in Guangxi Zhuang Autonomous Region. The group specific amplification was employed to characterize 107 individuals' genotype and haplotype of HLA clusters. Different models statistics such as relative risk test, correlation test and linkage disequilibrium analysis were used to analyze the data.</p><p><b>RESULTS</b>The results showed that there is a linkage disequilibrium between nonresponse to Hepatitis B vaccine and HLA haplotype DR4, 1122 (DRB1 * 0401- 22, 1122)-DR53 (DRB4 * 0101101, 0102/3)-DQB4 (DQB1 * 04).</p><p><b>CONCLUSION</b>In Chinese population, nonresponse to hepatitis B vaccine is highly associated with special HLA haplotye.</p>
Full text:
1
Database:
WPRIM
Main subject:
Haplotypes
/
HLA-DQ Antigens
/
HLA-DR Antigens
/
Linkage Disequilibrium
/
China
/
Classification
/
Hepatitis B Vaccines
/
Asian People
/
Allergy and Immunology
/
HLA-DQ beta-Chains
Type of study:
Etiology_studies
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Chinese Journal of Preventive Medicine
Year:
2002
Document type:
Article