Effect of c-kit mutation on the prognosis of gastrointestinal stromal tumors: a meta-analysis / 中华外科杂志
Chinese Journal of Surgery
; (12): 857-862, 2009.
Article
in Zh
| WPRIM
| ID: wpr-299722
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of c-kit mutation on the prognosis of gastrointestinal stromal tumors.</p><p><b>METHODS</b>A search of studies in PubMed and MedLine (from 1999 to 2008) was performed to assess the effect of c-kit mutation on the prognosis of gastrointestinal stromal tumors. The articles were retrieved with the entries of "gastrointestinal stromal tumors", "imatinib", "c-kit" and "mutation". A meta-analysis was performed to assess the data included.</p><p><b>RESULTS</b>A total of 15 articles were collected in this analysis. No significant differences was found in incidence of mitoses (> 5/50 HPF) between the patients with wild type c-kit (wild type group) and the ones with mutated c-kit (mutation group) (P = 0.710); tumor recurrence and metastasis rate after surgery was significant higher in the mutation group than that in wild type group (P = 0.010); as for imatinib response with different c-kit mutation types, the results showed the incidence of clinical response (complete response + partial response) was significantly higher in mutation group than that in wild type group (P = 0.009), but the imatinib resistance rate was lower in mutation group (P = 0.000); three studies provided data for imatinib resistance with c-kit second mutations, the results showed the second mutations mainly focus on exon 13, 14, 17.</p><p><b>CONCLUSIONS</b>C-kit mutation is related closely with the incidence of recurrence and metastasis in GIST after surgery. The mutations of c-kit influences the therapeutic effects of imatinib.</p>
Full text:
1
Database:
WPRIM
Main subject:
Piperazines
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Prognosis
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Pyrimidines
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Benzamides
/
Case-Control Studies
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Proto-Oncogene Proteins c-kit
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Therapeutic Uses
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Gastrointestinal Stromal Tumors
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Drug Therapy
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Imatinib Mesylate
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Surgery
Year:
2009
Document type:
Article