AZF microdeletions and partial deletions of AZFc region on the Y chromosome in Moroccan men / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
; (6): 674-678, 2007.
Article
in En
| WPRIM
| ID: wpr-310467
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To evaluate for the first time the frequency of Y chromosome microdeletions and the occurrence of the partial deletions of AZFc region in Moroccan men, and to discuss the clinical significance of AZF deletions.</p><p><b>METHODS</b>We screened Y chromosome microdeletions and partial deletions of the AZFc region of a consecutive group of infertile men (n = 149) and controls (100 fertile men, 76 normospermic men). AZFa, AZFb, AZFc and partial deletions of the AZFc region were analyzed by polymerase chain reaction (PCR) according to established protocols.</p><p><b>RESULTS</b>Among the 127 infertile men screened for microdeletion, four subjects were found to have microdeletions two AZFc deletions and two AZFb+AZFc deletions. All the deletions were found only in azoospermic subjects (4/48, 8.33%). The overall AZFc deletion frequency was low (4/127, 3.15%). AZF microdeletions were not observed in either oligoasthenoteratozoospermia (OATS) or the control. Partial deletions of AZFc (gr/gr) were observed in a total of 7 of the 149 infertile men (4.70%) and 7 partial AZFc deletions (gr/gr) were found in the control group (7/176, 3.98%). In addition, two b2/b3 deletions were identified in two azoospermic subjects (2/149, 1.34%) but not in the control group.</p><p><b>CONCLUSION</b>Our results suggest that the frequency of Y chromosome AZF microdeletions is elevated in individuals with severe spermatogenic failure and that gr/gr deletions are not associated with spermatogenic failure.</p>
Full text:
1
Database:
WPRIM
Main subject:
Reference Values
/
Spermatogenesis
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Diagnostic Imaging
/
Ultrasonography
/
Sequence Deletion
/
Seminal Plasma Proteins
/
Chromosomes, Human, Y
/
Genetic Loci
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Fertility
/
Genetics
Type of study:
Diagnostic_studies
/
Guideline
Limits:
Humans
/
Male
Country/Region as subject:
Africa
Language:
En
Journal:
Asian Journal of Andrology
Year:
2007
Document type:
Article