Risk Factors for Severe Adenovirus Infection in Children during an Outbreak in Singapore
Annals of the Academy of Medicine, Singapore
; : 50-59, 2015.
Article
in En
| WPRIM
| ID: wpr-312205
Responsible library:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>Human adenoviruses (HAdVs) can cause a variety of human illnesses, with associated temporal and geographic changes in disease incidence. We report the emergence of an outbreak of HAdV infections in Singapore, presumably caused by a change of the predominating type to HAdV-7. We examined the clinical features of children admitted with HAdV infection to 1 institution and the risk factors for severe infection.</p><p><b>MATERIALS AND METHODS</b>This is a retrospective case-control study of all HAdV-infected children admitted during weeks 1 to 19 in 2013, as identified from laboratory records. A descriptive retrospective analysis of epidemiology, clinical data and the outcome of these children was also performed. Patients with severe infections were defined as cases, those with non-severe infections as controls, and the 2 groups were compared to find possible independent risk factors.</p><p><b>RESULTS</b>Eighty-five patients with HAdV infection were studied, including 11 (12.9%) cases and 74 (87.1%) controls. Binary logistic regression showed that cases were more likely to be <2 years old (adjusted OR 10.6, 95% CI, 1.8 to 63.2) and to have significant comorbidities (adjusted OR 19.9, 95% CI, 3.4 to 116.1) compared to controls. The predominant type in 2013 was HAdV-7, which differed from 2011 and 2012, when HAdV-3 was more common. There was a trend towards pneumonia being more common in patients infected with HAdV-7 than in patients infected with other types, although this did not reach statistical significance (OR 2.8, 95% CI, 0.9 to 8.7).</p><p><b>CONCLUSION</b>The emergence of HAdV-7 in a population where other HAdV types had circulated previously may have caused the outbreak in Singapore, and this was associated with more serious infections in children. Young age (<2 years) and significant comorbidities were associated with more severe HAdV infection.</p>
Full text:
1
Database:
WPRIM
Main subject:
Singapore
/
Virology
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Virulence
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Severity of Illness Index
/
Case-Control Studies
/
Comorbidity
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Adenoviruses, Human
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Epidemiology
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Disease Outbreaks
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Retrospective Studies
Type of study:
Etiology_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Country/Region as subject:
Asia
Language:
En
Journal:
Annals of the Academy of Medicine, Singapore
Year:
2015
Document type:
Article