Pingyangmycin gelatin microspheres: preparation and drug release characteristics / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 646-649, 2003.
Article
in Zh
| WPRIM
| ID: wpr-312906
Responsible library:
WPRO
ABSTRACT
Pingyangmycin gelatin microspheres(PYM-GMS) was prepared by optimal double-phase emulsified condensation polymerization for the interventional Chemoembolization with carotid artery therapy, and its release characteristics were studied in vivo and in vitro. The results of three ways of administration(vein drop, artery perfusion and artery embolization) were compared. The experiment indicates that the diameter of PYM-GMS is more appropriate for the application in external carotid artery embolization with PYM-GMS, which significantly reduces the circulating drug level and the dosage, prolongs the time period of higher drug concentration, achieves the purpose of sustained release and targeted tumor therapy.
Full text:
1
Database:
WPRIM
Main subject:
Particle Size
/
Bleomycin
/
In Vitro Techniques
/
Infusions, Intravenous
/
Chemotherapy, Cancer, Regional Perfusion
/
Pharmacokinetics
/
Drug Compounding
/
Gelatin
/
Methods
/
Microspheres
Limits:
Animals
Language:
Zh
Journal:
Journal of Biomedical Engineering
Year:
2003
Document type:
Article