Study on gamma-synuclein gene in patients with idiopathic Parkinson's disease / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 444-446, 2003.
Article
in Zh
| WPRIM
| ID: wpr-329438
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the relationship between idiopathic Parkinson's disease (PD) and two polymorphisms (C243G and A377T) of the gamma-synuclein gene in a Chinese Han population of Shanghai area.</p><p><b>METHODS</b>Polymorphic genotyping was performed with PCR-RPLP technique. Association analysis was carried out in 145 unrelated idiopathic PD patients and 184 age-matched healthy controls.</p><p><b>RESULTS</b>The authors failed to detect any distributional difference of the C243G and A377T polymorphisms of the gamma-synuclein gene between PD cases and control subjects, nor did they find any association.</p><p><b>CONCLUSION</b>These data do not support that gamma-synuclein gene C243G and A377T polymorphisms are involved in idiopathic PD onset in the Han population of Shanghai area.</p>
Full text:
1
Database:
WPRIM
Main subject:
Parkinson Disease
/
Polymorphism, Single Nucleotide
/
Alleles
/
Synucleins
/
Gamma-Synuclein
/
Gene Frequency
/
Genetics
/
Genotype
/
Nerve Tissue Proteins
Limits:
Adult
/
Aged
/
Aged80
/
Humans
Language:
Zh
Journal:
Chinese Journal of Medical Genetics
Year:
2003
Document type:
Article