Human umbilical cord blood hematopoietic stem/progenitor cells can grow up in the mouse liver / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 391-394, 2002.
Article
in Zh
| WPRIM
| ID: wpr-337661
Responsible library:
WPRO
ABSTRACT
The biological characterization, differentiation and regeneration of hepatic stem/progenitor cells are the one of very active and interested fields. In this report, intravenous injection of human umbilical cord blood (HUCB) cells into the BALB/c-nu and SCID mice, an animal model for transplantation and liver injury, was reported. Using of flow cytometry and tissue typing (HLA), it was found that the HUCB cells were survived in mouse liver for 9 weeks. After separation from perfused liver, HUCB cells were detected by hematopoietic colonies (CFU-GEM M) in hepatocyte culture. It was concluded that the transplanted HUCB hematopoietic stem/progenitor cells can be survived in the liver over a long period of time.
Full text:
1
Database:
WPRIM
Main subject:
Physiology
/
Hematopoietic Stem Cells
/
HLA-DR Antigens
/
Cell Division
/
Mice, SCID
/
Hematopoietic Stem Cell Transplantation
/
Cell Biology
/
Fetal Blood
/
Flow Cytometry
/
Liver
Limits:
Animals
/
Humans
/
Male
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2002
Document type:
Article