Treatment of allergic rhinitis with asthma by different ways of inhaling corticosteroids / 中华耳鼻咽喉头颈外科杂志
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
; (12): 16-20, 2009.
Article
in Zh
| WPRIM
| ID: wpr-339238
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the therapeutical effect on allergic rhinitis with asthma by different ways of inhaling corticosteroids.</p><p><b>METHODS</b>Ninety patients suffering from allergic rhinitis with asthma were classified into three groups in random and treated with budesonide (BUD) by nasal spray, inhaling and nasal spray-inhaling combined administration for 12 weeks, respectively. The concentration of serum total IgE, eosinophil cationic protein (ECP) and IL-5, pulmonary functions were examined before and after treatment.</p><p><b>RESULTS</b>The improvement of symptom scores of rhinitis and asthma in three groups were significant (P < 0.05). The concentration of serum total IgE, ECP and IL-5 in three groups decreased greatly after treatment (P < 0.05). There were significant improvement in FEV1, FEV1/FVC and FEF25%-75% in inhaling group before and after treatment (P < 0.05): FEV1 from (2.04 +/- 0.45) L to (2.47 +/- 0.54) L, FEV1/FVC from (72.73 +/- 5.59)% to (75.42 +/- 5.94)% and FEF25%-75% from 1.69 +/- 0.52 to 2.06 +/- 0.77. There was also significant improvement in nasal spray-inhaling combined groups before and after treatment (P < 0.05): FEV1 from (2.32 +/- 0.56) L to (2.76 +/- 0.58) L, FEV1/FVC from (73.80 +/- 4.17)% to (76.04 +/- 4.49)% and FEF25%-75% from 2.09 +/- 0.45 to 2.34 +/- 0.64. The significant difference of FEV1 among the three treatment groups was observed (P = 0.041).</p><p><b>CONCLUSIONS</b>The symptoms of rhinitis and asthma in three groups by three ways of inhaling BUD were greatly improved, no significant difference in symptom scores and serum parameters was found.</p>
Full text:
1
Database:
WPRIM
Main subject:
Asthma
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Blood
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Immunoglobulin E
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Rhinitis, Allergic, Perennial
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Interleukin-5
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Treatment Outcome
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Adrenal Cortex Hormones
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Budesonide
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Therapeutic Uses
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Eosinophil Cationic Protein
Limits:
Adult
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Female
/
Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Year:
2009
Document type:
Article