CD34+ antigen expression relating to prognosis in acute myeloid leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 812-814, 2005.
Article
in Zh
| WPRIM
| ID: wpr-343881
Responsible library:
WPRO
ABSTRACT
To explore CD34(+) antigen expression in new diagnosed acute myeloid leukemia (AML) and analyze the prognosis for CD34(+) AML patients, the expression of antigen CD34 in 238 AML patients was detected by indirect immunofluorescence assay. The results showed that CD34 in 92 out of the 238 patients (38.7%) were positive, there was relationship between the CD34(+) expression and FAB subtypes (M(0), M(1)), and no CD34(+) expression was observed in M(3) subtypes. The complete remission rate of CD34(+) AML patients was 32%, which was lower than that of CD34(-) AML (61%). The lymphoid-associated antigen (CD7) was significantly increased in CD34(+) AML patients, compared with CD34(-) patients (P < 0.05). It is concluded that CD34(+) AML patients show poor prognosis and lower CR rate. The detection of CD34 expression is of some value in predicting prognosis in AML.
Full text:
1
Database:
WPRIM
Main subject:
Pathology
/
Prognosis
/
Leukemia, Myelomonocytic, Acute
/
Leukemia, Myeloid, Acute
/
Leukemia, Monocytic, Acute
/
Fluorescent Antibody Technique, Indirect
/
Antigens, CD7
/
Antigens, CD34
/
Metabolism
Type of study:
Prognostic_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2005
Document type:
Article