Effects of growth differentiation factor-15 (GDF-15) on neurological systems, cardiovascular diseases, and cancer progression / 生理学报
Acta Physiologica Sinica
; (6): 109-121, 2017.
Article
in Zh
| WPRIM
| ID: wpr-348293
Responsible library:
WPRO
ABSTRACT
Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor beta superfamily. GDF-15 expression is dramatically upregulated during acute brain injury, cancer, cardiovascular disease, and inflammation, suggesting its potential value as a disease biomarker. It has been suggested that GDF-15 has neurotropic effects in the nervous system. Our studies showed that GDF-15 modulated the expression of neuronal Kand Caion channels and increased the release of excitatory transmitter in the medial prefrontal cortex of mice. GDF-15 is also involved in the complex modulation of cancer and cardiovascular disease. Here, we reviewed studies involving the modulation of GDF-15 expression and its mechanisms, the primary pathological and physiological functions of GDF-15 in neurological and cardiovascular systems, and its role in cancer progression. The biological effects and the values of GDF-15 in basic research and clinical applications were also addressed.
Full text:
1
Database:
WPRIM
Main subject:
Brain Injuries
/
Calcium Channels
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Cardiovascular Diseases
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Potassium Channels
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Up-Regulation
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Transforming Growth Factor beta
/
Prefrontal Cortex
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Disease Progression
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Growth Differentiation Factor 15
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Inflammation
Limits:
Animals
/
Humans
Language:
Zh
Journal:
Acta Physiologica Sinica
Year:
2017
Document type:
Article