Clinical and cytogenetic features and their influencing factors of core binding factor acute myeloid leukemia / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 517-524, 2011.
Article
in Zh
| WPRIM
| ID: wpr-352995
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To discuss the clinical and cytogenetic features of core binding factor (CBF) acute myeloid leukemia (AML) patients and the main factors that influence the prognosis.</p><p><b>METHOD</b>Totally 130 CBF AML patients were followed up and their clinical features, immunophenotype, chromosome karyotype, treatment regimen, overall survival (OS), and relapse-free survival (RFS) were analyzed.</p><p><b>RESULTS</b>The overall complete remission (CR) rate was 96.1%, among which the CR rate after the first treatment course was 77.2%. The overall median OS was 51.64 (0.26-132.5) months, while the median RFS did not reach 1.18-96.62 months. The 3-year OS was 50% and the 5-year OS was 41%; the 3-year RFS was 59% and the 5-year RFS was 54%. Patients who were over 45 years and those with chromosome karyotype of 9q- tended to have poorer prognosis. During the consolidating chemotherapy, patients who had received two or more courses of intermediate-dose Ara-C therapy had better prognosis and longer survival. AML patients with inv (16) /t (16; 16) had a significantly higher OS than those with t (8; 21) (P = 0.046), while the RFS showed an opposite finding (P = 0.038).</p><p><b>CONCLUSIONS</b>Age, chromosomal karyotype, and consolidating chemotherapy are the main factors that influence the survival and prognosis of CBF AML patients. Two or more courses of intermediate-dose Ara-C during consolidating chemotherapy can obviously prolong the OS and RFS of CBF AML patients. AML patients with a chromosomal karyotype of inv (16) /t (16; 16) have longer OS and better prognosis than those with t (8; 21).</p>
Full text:
1
Database:
WPRIM
Main subject:
Prognosis
/
Therapeutics
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Leukemia, Myeloid, Acute
/
Survival Rate
/
Follow-Up Studies
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Core Binding Factors
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Genetics
/
Karyotyping
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Acta Academiae Medicinae Sinicae
Year:
2011
Document type:
Article