Effects of maleic anhydride-modified poly(D,L-lactic acid) on the adhesion, proliferation and differentiation of osteoblasts / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 753-757, 2011.
Article
in Zh
| WPRIM
| ID: wpr-359186
Responsible library:
WPRO
ABSTRACT
The main objective of this study was to observe the adhesion, proliferation and differentiation of mouse osteblast-like MC3T3-E1 cells cultured on maleic anhydride-modified poly(D,L-lactic acid) (MPLA) and poly(D,L-lactic acid) (PDLLA) polymers, and to evaluate the cytocompatibility of MPLA polymer. The effects of MPLA and PDLLA polymers on the morphology, adhesion, proliferation, the content of total cellular protein, alkaline phosphatase (ALP) activity and the content of Ca of MC3T3-E1 cells were explored. These results indicated that MC3T3-E1 cells on MPLA polymer adhered and spread more fully. On MPLA polymer, the proliferation, total protein content, ALP activity, Ca content of the cells were significantly higher than those of the cells on PDLLA polymer (P < 0.01). It was concluded that MPLA polymer could promote the adhesion, spreading, proliferation and the synthesis of protein of osteoblasts, and also induced the differentiation and mineralization of osteoblasts, suggesting that MPLA polymer might have the better cytocompatibility than PDLLA.
Full text:
1
Database:
WPRIM
Main subject:
Osteoblasts
/
Pharmacology
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Polyesters
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Polymers
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Biocompatible Materials
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Cell Adhesion
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Cell Differentiation
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Cell Line
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Chemistry
/
Lactic Acid
Limits:
Animals
Language:
Zh
Journal:
Journal of Biomedical Engineering
Year:
2011
Document type:
Article