Identification of metabolites of arbidol by ultra-high performance liquid chromatography tandem mass spectrometry / 药学学报
Acta Pharmaceutica Sinica
; (12): 1521-6, 2012.
Article
in Zh
| WPRIM
| ID: wpr-433008
Responsible library:
WPRO
ABSTRACT
UPLC-MS-MS system was used for the identification of arbidol metabolites in the rat feces, urine and plasma samples. The system was so powerful a way with high ability of separation and analysis, based on both chromatography and mass properties. The isotope of Br was also a good indicator for metabolites finding. There were altogether 9 metabolites detected and identified, including 2 phase I biotransformation products and 7 phase II ones. It is concluded that arbidol mainly undergo metabolic reactions such as N-demethylation, S-oxidation, glucuronidation and sulfation in rats.
Full text:
1
Database:
WPRIM
Type of study:
Diagnostic_studies
/
Prognostic_studies
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Document type:
Article