Expression of RRM1 in gastric adenocarcinoma and its relationship with clinical pathological characteristics / 国际肿瘤学杂志

ABSTRACT

Objective To investigate the expression of human ribonucleotide reductase large subunit M1 (RRM1) in the patients with gastric adenocarcinoma and its clinical significance.Methods The expressions of RRM1 were detected in 88 cases of gastric adenocarcinoma and 20 cases of nonnal gastric tissues by immunohistochemical method.The correlations between the expression of RRM1 and clinicopathological characteristics were analyzed.Results The positive expression rate of RRM1 in gastric adenocarcinoma was 83.0％(73/88).And RRM1 was negative in the entire normal gastric tissues.The positive expression of RRM1 was not associated with patient's age (x2 =0.352,P=0.553),gender (x2 =0.493,P=0.482),depth of tumor infiltration depth (x2 =0.007,P =0.933),lymph nodes metastasis (x2 =0.121,P =0.728) and distant metastasis (P =0.415).But it was related to the degree of tumor differentiation (x2 =7.740,P =0.021) and clinical stage (x2 =5.733,P =0.017).Conclusion The expression of RRM1 is positive expression in most gastric adenocarcinoma,and is associated with the degree of tumor differentiation and clinical stage.It is of great significance to detect the expression of RRM1 in gastric adenocarcinoma for confirming the diagnosis and judging malignant degree of the tumor.It also may have potential value in choosing the best therapeutic scheme and estimating prognosis.