The Ototoxicity of Amikacin With Therapeutic Doses on Neonatal Guinea-pigs / 中华围产医学杂志

ABSTRACT

Objective To explore the possibility of ototoxicity of aminoglycosides on neonatal guinea pigs of different age groups (including premature) receiving amikacin with therapeutic doses. Methods Amikacin was injected intramuscularly with a dose of 65 mg/kg once a day for 14 days in neonatal, infant, and adult groups with 48 guinea pigs each, and 15 in premature group. 5~8 guinea pigs in each group were sacrificed for histological examination of cochlea with microscopy and scanning electron microscopy on the 3 rd, 5 th, 7 th, 10 th and 14 th day, as well the 28 th, 60 th day. There were 6 guinea pigs in each age group for control. Results Many stereocilia were lain down or disappeared as early as the 3 rd day and outer hair cells were absent on the 5 th day in either premature or neonatal group. The numbers of absent hair cells in neonatal group were more than those in infant and adult groups after the 7 th day ( P