Study on the Association of HLA Class Ⅱ Genes with Vitiligo in the Eastern China Han Nationality / 中华皮肤科杂志
Chinese Journal of Dermatology
; (12)2003.
Article
in Zh
| WPRIM
| ID: wpr-522869
Responsible library:
WPRO
ABSTRACT
Objective To investigate the association of HLA class Ⅱ genes and vitiligo in the eastern China Han nationality. Methods Ninety-eight patients with vitiligo and 150 healthy controls were studied for HLA-DRB1, DQA1 and DQB1 locus alleles by PCR-SSOP typing. Results The frequency of HLA-DQA1*03 increased significantly (Pc = 0.008) and DQA1*05 decreased significantly (Pc = 0.016) in the patients with vitiligo. Conclusions The results suggest that there exists a correlation between HLA class Ⅱ genes and vitiligo, and DQA1*03 allele may be a susceptible gene or have a close linkage with susceptible genes, while DQA1*05 allele may be a protective gene in the eastern China Han nationality.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Dermatology
Year:
2003
Document type:
Article