Mutation and expression of ?-catenin gene in breast cancer / 中国普通外科杂志
Chinese Journal of General Surgery
; (12)1993.
Article
in Zh
| WPRIM
| ID: wpr-528846
Responsible library:
WPRO
ABSTRACT
Objective To investigate the role of ?-catenin gene in breast tumorigenesis.Methods Mutation and expression of ?-catenin gene in 42 breast cancer tissues were detected by polymerase chain reaction-single strand conformation polymorphism and immunohistochemistry.Results The rate of abnormal expression of ?-catenin in breast cancer tissuse was 59.5%(25/42).Mutation of ?-catenin gene was not detected in breast cancer tissue.Conclusions Abnormal expression of ?-catenin plays an important role in human breast tumorigenesis,but the cause of abnormal expression of ?-catenin is not mutation of ?-catenin gene.
Full text:
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Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of General Surgery
Year:
1993
Document type:
Article