Determination of Aripiprazole in Human Plasma by HPLC / 中国药房
China Pharmacy
; (12)1991.
Article
in Zh
| WPRIM
| ID: wpr-528870
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To establish a HPLC method for the determination of aripiprazole in human plasma by HPLC.METHODS:
The plasma sample was determined by HPLC after subjected to liquid- liquid extraction .The separation was carried out on C18 column with clolumn temperature at 40℃. The mobile phase consisted of 0.03mol?L-1 ammonium acetate-acetonitrile(3466) with a flow rate of 0.8mL?min-1 and detective wavelength of 257nm.The sensitivity was 0.01 AUFS.RESULTS:
The linear range of aripiprazole was 5.0~600.0ng?mL-1(r=0.999 5) .The recovery rate was above 90% .CONCLUSION:
The method is sensitive,accurate and rapid,and suitable for the determination of aripiprazole in human plasma.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
China Pharmacy
Year:
1991
Document type:
Article