Assessment of Abdominal Fat and Mid-Thigh Low-Density Muscle Areas in Patients with Schizophrenia / 대한정신약물학회지
Korean Journal of Psychopharmacology
; : 81-85, 2007.
Article
in Ko
| WPRIM
| ID: wpr-53645
Responsible library:
WPRO
ABSTRACT
OBJECTIVE: Patients with schizophrenia are at a higher risk for developing insulin resistance and type 2 diabetes mellitus (T2DM). However, few studies have examined abdominal fat and mid-thigh low-density muscle areas, which are known risk factors for insulin resistance and T2DM, in patients with schizophrenia. Therefore, we measured the abdominal fat and mid-thigh low-density muscle areas of schizophrenics and compared them with normal controls. METHODS: Nineteen (four men and 15 women) drug-naive or -free subjects who met the DSM IV criteria for schizophrenia and 19 age- and sex-matched controls were recruited. We measured weight, height, waist circumference, and percent body fat, and calculated the body mass index (BMI). Abdominal fat and mid-thigh low-density muscle areas were evaluated using computed tomography. RESULTS: There was no significant difference in terms of age and BMI between the two groups. The areas of abdominal fat (262.4+/-101.8 vs. 257.1+/-93.8 cm2 ; p=0.919), subcutaneous fat (182.4+/-72.8 vs. 180.5+/-75.1 cm2 ; p=0.988), visceral fat (79.9+/-47.2 vs. 76.6+/-49.3 cm2 ; p=0.872), and mid-thigh low-density muscle (15.0+/-9.9 vs. 15.4+/-5.2 cm2, p=0.373) did not differ between schizophrenics and controls. CONCLUSION: Abdominal obesity is a well-recognized risk factor for developing certain medical conditions such as insulin resistance and T2DM. We demonstrated that drug-naive or- free patients with schizophrenia do not have increased visceral fat or mid-thigh low-density muscle areas, which might have explained the higher prevalence of insulin resistance and T2DM in these patients.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Schizophrenia
/
Insulin Resistance
/
Body Mass Index
/
Adipose Tissue
/
Prevalence
/
Risk Factors
/
Diabetes Mellitus, Type 2
/
Abdominal Fat
/
Intra-Abdominal Fat
/
Subcutaneous Fat
Type of study:
Etiology_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Humans
/
Male
Language:
Ko
Journal:
Korean Journal of Psychopharmacology
Year:
2007
Document type:
Article