Evaluation of the security and biocompatibility of bioabsorbable composites PDLLA-CPP / 西安交通大学学报(医学版)
Article
in Zh
| WPRIM
| ID: wpr-541131
Responsible library:
WPRO
ABSTRACT
Objective To evaluate the security and biocompatibility of a new kind of absorbable high-strength PDLLA-CPP composite, which is used for internal fracture fixation. Methods According to the national standard of the procedure of appraise in food security and toxicology, micronucleus test of bone marrow cell, spermatic aberration test, chromosomal aberration test, and teratogenic test were measured with IP maximal tolerance dose of maceration extract from PDLLA-CPP composites. Meanwhile, chondrocyte culture with PDLLA-CPP composite was used to evaluate the effect of PDLLA-CPP composite on cartilage cell proliferation. Results Micronucleus test of bone marrow cell, spermatic aberration test, chromosomal aberration test, and teratogenic test were not affected by IP maximal tolerance dose of PDLLA-CPP maceration extract. PDLLA-CPP composite also had no cytotoxicity on cartilage cell proliferation. Conclusion PDLLA-CPP is a new and safe medical material with good biocompatibility and absorbability.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Journal of Xi'an Jiaotong University(Medical Sciences)
Year:
1981
Document type:
Article