EFFECT OF PANAXATRIOL SAPONIN ( PTS ) ON HUMAN LYMPHOKINE PRODUCTION AND ITS CHARACTERISTICS / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)1987.
Article
in Zh
| WPRIM
| ID: wpr-550157
Responsible library:
WPRO
ABSTRACT
Under stimulation of PHA,PHA + TPA,or PHA + PTS the time ke-netics of DNA,RNA,protein synthesis and lymphokine secretion by human lymph node cell expressed different responses. The PTS did not increase the DNA and RNA synthesis, but increased the protein synthesis ( 60% ) . TPA increased the RNA synthesis ( 18% ) , therefor increased the protein synthesis ( 40% ) . Both of TPA and PTS increased the production of 5 kinds of lymphokines (IL-1 , IL-2 , IL-3, BCGF, TFNr). We infer that PTS and TPA increase the lymphokine production through different gene regulation. TPA Promotes the translation of lymphokine mRNA。
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
1987
Document type:
Article