Association of single nucleotide polymorphism in mdr1C3435T with susceptibility to ovarian cancer / 重庆医科大学学报
Journal of Chongqing Medical University
; (12)2007.
Article
in Zh
| WPRIM
| ID: wpr-580425
Responsible library:
WPRO
ABSTRACT
Objective:
To investigate the association of single nucleotide polymorphism in mdr1C3435T with susceptibility to ovarian cancer.Methods:
mdr1C3435T gene was determined by PCR-RFLP method in 135 ovarian cancer patients(cases group) and 146 healthy women(control group).Results:
The frequency of C/C genotype in cases group(30.37%) was significantly lower than that in controls(47.95%),and the frequencies of T/C(44.44%)and T/T(25.19%) respectively in cases group were significantly higher than those in controls(T/C38.35%,T/T13.7%).The frequency of mdr1C3435T null genotype in cases group(25.19%) was higher than that in control group(13.7%).Compared with controls,the susceptibility of ovarian cancer with the T/T genotype was increased by 2.121-fold.There was significant difference in frequency of mdr1C3435T null and nonnull genotype between cases and controls of average age(P
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Journal of Chongqing Medical University
Year:
2007
Document type:
Article