Determination of Nicotinate-curcumin Ester and Its Nanoparticles by HPLC / 中国药师
China Pharmacist
; (12): 1181-1184, 2017.
Article
in Zh
| WPRIM
| ID: wpr-617508
Responsible library:
WPRO
ABSTRACT
Objective:
To provide basis for the preparation process study by establishing an HPLC determination method for nicotinate-curcumin ester.Methods:
A C18 column(250 mm×4.6 mm,5 μm) was used at 30℃ with the mobile phase of acetonitrile-0.5% acetic acid glacial(65∶35) at a flow rate of 1.0 ml·min-1.The UV detection wavelength was 280 nm.Results:
The good linear relationship of nicotinate-curcumin ester was shown within the range of 5.200-104.000 μg · ml-1(r=0.9999 4), The average recovery of nicotinate-curcumin ester and its nanoparticles was 100.1% and 100.9%with RSD of 1.260% and 0.995 0%(n=6), respectively.Conclusion:
The method is convenient, accurate and reproducible, and suitable for the determination of nicotinate-curcumin ester nanoparticles and the studies on the preparation technology.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
China Pharmacist
Year:
2017
Document type:
Article