Effect of Acupuncture on Cerebral Glial Fibrillary Acidic Protein Expression of Brain Injury Caused by Intrauterine Infection in Neonatal Rats / 实用儿科临床杂志
Journal of Applied Clinical Pediatrics
; (24)2006.
Article
in Zh
| WPRIM
| ID: wpr-639321
Responsible library:
WPRO
ABSTRACT
Objective To observe the effect of acupuncture on cerebral glial fibrillary acidic protein(GFAP)expression of brain injury caused by intrauterine infection in neonatal rats.Methods Forty-three Wistar pregnant rats were divided into 2 groupslipopolysaccharide(LPS)(n=35)and normal saline(n=8).Pregnant rats were consecutively injected intraperitoneally with LPS(450 ?g/kg)or saline on gestation 17 d and 18 d.LPS group were randomly divided into acupuncture group and model group.Acupuncture group were given acupunctured from 7 d to 21 d.GFAP expression was assayed with immunohistochemical technique.Results The number of GFAP immunoreaction(IR)strongly-positive neurons in the cerebral white matter was more in acupuncture group,less in model group and only very weakly IR-positive neurons were found in normal saline group.Conclusion Acupuncture can up-regulate the expression of GFAP in the cerebral white matter,which may contribute to the effect of acupuncture in improving brain injury caused by intrauterine infection.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Journal of Applied Clinical Pediatrics
Year:
2006
Document type:
Article